From Bowling Green, Kentucky:
Take the William Natcher Parkway to Owensboro. Get on U.S. 231 north, which will take you into Spencer County, Indiana. (Approximate travel time: 2 hours)

From Chicago, Illinois:
Take Route 90 southeast to I-65 south in Indiana. Take I-465 south and west around Indianapolis. Continue on I-65 south. Take I-265 west to I-64 west. Stay on I-64 for nearly an hour, then take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 6 hours)

From Cincinnati, Ohio:
Take I-71 south to Louisville, then take Exit 173 and continue on the ramp. Merge onto I-71 south and stay on it for approximately 1 hour and 10 minutes, then take Exit 1 to I-64 west. Continue on I-64 west for approximately 1 hour then take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 3 hours)

From Detroit, Michigan:
Take I-69 south to Indianapolis, then I-65 south nearly to Louisville. Take I-265 west to I-64 west. Stay on I-64 west for nearly an hour, then take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 6.5 hours)

From Indianapolis, Indiana:
Take I-65 south, nearly to Louisville. Take I-265 west to I-64 west. Drive west on I-64 for nearly an hour, then take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 3 hours)

From Lexington, Kentucky:
Take I-64 west into Indiana for approximately 2 hours until you reach Exit 63 or Exit 57. Take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 2 hours)

From Louisville, Kentucky:
Take I-64 west into Indiana and continue west for just under an hour. Take Exit 63 and turn left (south) onto Highway 162; or take Exit 57 and turn left (south) onto U.S. 231 into Spencer County, Indiana. (Approximate travel time: 1 hour)

From Mt. Vernon, Illinois:
Take I-64 east for approximately 1 hour and 45 minutes. Take Exit 57 and head south (turn right) on U.S. 231. (Approximate travel time: 2 hours)

From Nashville, Tennessee:
Take I-65 to Bowling Green, Kentucky. Then take the William Natcher Parkway to Owensboro, Kentucky. Get on U.S. 231 north, which will take you into Spencer County, Indiana. (Approximate travel time: 3 hours)

From Owensboro, Kentucky:
Get on U.S. 231 north, which will take you into Spencer County, Indiana. (Approximate travel time: 15 minutes)

From Paducah, Kentucky:
Take U.S. 60 east to Owensboro. Get on U.S. 231 north, which will take you into Spencer County, Indiana. (Approximate travel time: 3 hours)

From St. Louis, Missouri:
Drive on I-64 east for approximately 3 hours; take Exit 57 in Indiana. Head south (turn right) on U.S. 231. (Approximate travel time: 3 hours)

From Terre Haute, Indiana:
Take U.S. 41 south to Interstate 64. Go east on I-64 for close to an hour. Take Exit 57 and head south (turn right) on U.S. 231. (Approximate travel time: 2 hours)